Mesalazine interstitial nephritis presenting as colitis ulcerosa exacerbation
| Journal | Volume 69 - 2006 |
| Issue | Fasc.3 - Case reports |
| Author(s) | S. Van Biervliet, A. Raes, J. Vande Walle, M. Van Winckel, E. Robberecht, M. Praet |
| Full article |
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| Departments of (1) Paediatric Gastroenterology ; (2) Nephrology and (3) Pathology, Ghent University Hospital, Ghent, Belgium. |
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Mesalazine is the first line treatment in paediatric inflammato- ry bowel disease (IBD). There are several reports in the literature about nephrotoxicity (1/150 treated patients), from renal insuffi- ciency to reversible nephritis. It is currently advised to follow cre- atinin in patients treated with mesalazine during the first 5 years of treatment ; however this may reveal the problem too late. As demonstrated in this paediatric case, a high degree of clinical sus- picion is needed to diagnose the side effects before irreversible kid- ney damage occurs. Since the treatment of IBD exacerbation and mesalazine induced interstitial nephritis is based upon steroids, delayed diagnosis of the latter is at risk. (Acta gastroenterol. belg., 2006, 69, 321-322). |
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© Acta Gastro-Enterologica Belgica. |
